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KMID : 0380219930260050473
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Journal of Biochemistry and Molecular Biology
1993 Volume.26 No. 5 p.473 ~ p.478
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Interrelationship Between Transglutaminases and Silicotic Nodule Formation in Rats
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Soo Young Lee
Ghap Joo Ghim/Joo Won Lim/Young Woo Song and Joon Ho Kim
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Abstract
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The interrelationship between transglutaminases (TGases, EC 2.3.2.13) and silicotic nodule formation in rat lung resulting from experimentally induced silicosis, was studied. The activity of cytosolic TGase C was reduced at the time of silicotic nodule formation, whereas no significant change in the activity of particulate or matrix-associated TGase B associated with an increase in TGase B/TGase C ratios, was found. TGase B may play a role in catalyzing gamma-carboxamide crosslinking to fibrosis in the formation of silicotic nodules.
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